GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THYM | cis | rs7989332 | 1 | rs7989332 | chr13:21050575 | GJB2 | chr13:20761606-20767114:- | -0.36 | -4.82 | 5.51E-6 | Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) |
| THYM | cis | rs757978 | 1 | rs80085676 | chr2:242347907 | SEPT2 | chr2:242254723-242293439:+ | 0.44 | 5.87 | 6.46E-8 | Chronic lymphocytic leukemia |
| THYM | cis | rs8010715 | 1 | rs8010715 | chr14:24609147 | FAM158A | chr14:24608175-24610797:- | -0.3 | -9.69 | 7.56E-16 | IgG glycosylation |
| THYM | cis | rs2143950 | 1 | rs8013540 | chr14:35513760 | KIAA0391 | chr14:35591776-35786673:+ | 0.32 | 4.18 | 6.43E-5 | Atopic dermatitis |
| THYM | cis | rs2143950 | 1 | rs8013540 | chr14:35513760 | PPP2R3C | chr14:35554679-35591679:- | 0.27 | 5.03 | 2.32E-6 | Atopic dermatitis |
| THYM | cis | rs73726531 | 1 | rs80152842 | chr6:18109498 | NHLRC1 | chr6:18120718-18122851:- | -1.06 | -4.36 | 3.24E-5 | Thiopurine S-methyltransferase activity |
| THYM | cis | rs8028182 | 1 | rs8028182 | chr15:75718669 | MAN2C1 | chr15:75648135-75660941:- | 0.62 | 7.05 | 2.87E-10 | Sudden cardiac arrest |
| THYM | cis | rs2028299 | 1 | rs8031576 | chr15:90380214 | AP3S2 | chr15:90373832-90456222:- | -0.43 | -4.89 | 4.09E-6 | Type 2 diabetes |
| THYM | cis | rs2120019 | 1 | rs8033837 | chr15:75353975 | PPCDC | chr15:75315927-75343066:+ | 0.27 | 4.81 | 5.68E-6 | Blood trace element (Zn levels) |
| THYM | cis | rs2120019 | 1 | rs8036197 | chr15:75370232 | PPCDC | chr15:75315927-75343066:+ | 0.26 | 4.7 | 8.93E-6 | Blood trace element (Zn levels) |
| THYM | cis | rs9921338 | 1 | rs8049173 | chr16:11436882 | C16orf75 | chr16:11343506-11445617:+ | 0.28 | 4.37 | 3.13E-5 | Vein graft stenosis in coronary artery bypass grafting |
| THYM | cis | rs8050907 | 1 | rs8050324 | chr16:4613292 | NMRAL1 | chr16:4511696-4526307:- | -0.5 | -5.61 | 1.96E-7 | Obesity-related traits |
| THYM | cis | rs8050907 | 1 | rs8050907 | chr16:4646878 | NMRAL1 | chr16:4511696-4526307:- | -0.44 | -5.1 | 1.7E-6 | Obesity-related traits |
| THYM | cis | rs9921338 | 1 | rs8055427 | chr16:11436883 | C16orf75 | chr16:11343506-11445617:+ | 0.28 | 4.37 | 3.13E-5 | Vein graft stenosis in coronary artery bypass grafting |
| THYM | cis | rs8050907 | 1 | rs8061699 | chr16:4632723 | NMRAL1 | chr16:4511696-4526307:- | -0.48 | -5.55 | 2.6E-7 | Obesity-related traits |